This thesis also includes studies illustrating the conformational dynamics of the Escherichia coli chemoreceptors correlated to its signaling states, which gives crucial insights on how the receptors function in a trimers-of-dimers packing arrangement. This highlight that a structural diversity of chemoreceptor arrays does exist, and that is the norm and not an exception. This thesis presents the discovery of a different stoichiometry of chemotaxis proteins and a direct visualization of the kinase distribution within the chemosensory arrays in Vibrio cholerae. This thesis includes a general introduction of the basics of bacterial chemosensory and the structural diversity of chemosensory arrays, as well as a description of the workflow of using cryo electron tomography to image bacterial chemosensory arrays in situ. Cryo electron tomography is a technique of transmission electron microscopy that allows the visualization of protein complexes in their near-native cellular context. Show more Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals. This thesis also includes studies illustrating the conformational. Cryo electron tomography studies of bacterial chemosensory arrays Doctoral Thesis Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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